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Evidence is increasing that most addiction without exception is related to difficulties with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both once they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed pounds can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it one should err assisting caution and permit the FDA do its job and demand some study be done in order that the public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on the medications. Researchers found that participants using this drug for a year, dropped excess weight within a month and have kept the extra weight off through the 56 weeks of the study. Contrave is really a combination in the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs that are made up of more than one active ingredient, which may make them more efficient and safer. Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and therefore it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that by right now there are no long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug can also raise blood pressure levels and heartrate, and shouldn't be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not used in patients with uncontrolled high blood pressure levels, in addition to by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients having a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. Acamprosate also functions eliminate the wish to drink by eliminating the the cravings for drinking alcohol. The major difference between Naltrexone and Acamprosate is always that Acamprosate is just not yet available in the United States. While it may be widely studied in Europe the actual chemical reason that it works is still unknown. It is thought that it disturbs receptors inside the brain which process glutamate, which essentially alters the way ones body reacts to alcohol intake. Several of the European research has shown a lot of promise with Acamprosate in this some of the patients had a nearly double effectiveness for staying sober.